Sorafenat (sorafenib)|Natco|Anti Cancer Drugs|price in india
SORAFENAT
DESCRIPTION
Sorafenib sold under the brand name Sorafenat 200mg. Sorafenat 200mg Tablets belongs to the group of tyrosine kinase inhibitor or inhibitor of angiogensis. The drug is a type of targeted therapy Sorafenat 200mg is a prescription drug used under the supervision of health care provider.INDICATION
Sorafenat 200mg Tablets is a anticancer drug and indicated for the treatment of some condition as Advanced renal cell carcinoma Hepatocellular carcinoma Metastatic thyroid carcinoma |
| Sorafenat 200mg |
DOSAGE
IN RENAL CELL CARCINOMA
The dose of Sorafenat 200mg is given as 400mg should be taken orally as twice daily for at least one hour before or two hours after the meal
THYROID CARCINOMA
The dose of Sorafenat 200mg tablets is given as 400mg should be taken orally as twice daily for at least one hour before or two hours after the meal
HEPATOCELLULAR CARCINOMA
The usual dose of Sorafenat 200mg is given as 400mg should be taken orally as twice daily for at least one hour before or two hours after the meal.
SORAFENAT WORKS IN THE BODY
Sorafenat 200mg includes in deficiency of tumor cell multiplication Sorafenat 200mg interfere with multiple intracellular and cell surface kinase These enzymes are specific for tumor cell signaling, angiogenesis and apoptosis.Sorafenat 200mg Tablets causes to reduce the blood flow to the cancer cells By prohibiting these enzymes (kinase), genetic transcription includes in cell proliferation and angiogenesis is blocked.
DRUG INTERACTION
Interaction of Sorafenat 200mg with Rifampin a strong CYP3A4 inducer, administered at a dose of 600mg single use for 5 days with Sorafenat 200mg Tablets causes decrease AUC of Sorafenib 200mg Interaction with neomycin will reduce the AUC of Sorafenib 200mg Tablets Interaction with acetaminophen will raises the hepatoxicity effect of Sorafenib 200mg Interaction with Bevacizumab will increase the toxic effect of Sorafenib 200mg TabletsPRODUCTS DETAILS
Strength : 200mg
Manufactured : Natco
Package : 120 Tablets
BODY WORKS FOR THE DRUG SORAFENIB
ABSORPTION
The Sorafenat 200mg bioavailability is 38 to 49% The time to peak serum concentration in 3 hours. High fat meals may decrease the bioavailability of SorafenibDISTRIBUTION
The drug Sorafenat has Human plasma protein bound is 99.5%METABOLISM
In liver Sorafenat 200mg Tablets is highly metabolized, it go through oxidative metabolism with the help of CYP3A4 and Glucuronidation by UGT1A9 The main flowing metabolite in serum is pyridine N oxide
ELIMINATION
The dose excreted via feces 77% The dose excreted via urine 19% as glucuronidated metabolites Sorafenat 200mg half life is 25 to 48 hours
SAFETY PRECAUTIONS &
Sorafenat 200mg Tablets should not be used, in case of lung cancer, being treated with platinum containing chemo drugs and taxol drugs Sorafenatable to cause heart problems, stop the medicine in case of dizziness, fainting, sweating or shortening of breath Sorafenat causes severe bleeding; care should be taken while getting Sorafenat 200mg Stop the Tablet Sorafenat 200mg in case of;
blood in urine or stools, blood while coughing, Vaginal bleeding Hemorrhage risk QT prolongation. High occurrence of skin toxicity and rashes. Impairs exogenous thyroid suppression. Hypersentivity to the drug and any product of expicients.
Lymphopenia Neutropenia Hemorrhage Hypertension Neuropathy Anorexia Headache Joint pain Congestive heart failure Acute renal failure Angiodema arrhythmia Interstitial lung disease Post marketing reports: Hypersensitivity reactions: angioedema, anaphylactic reaction Hepatobiliary disorders: hepatitis, hepatic failure and death Musculoskeletal: rhabdomyolysis, osteonecrosis of the jaw Pulmonary: interstitial lung disease
SAFETY PRECAUTIONS &
CONTRAINDICATION
Sorafenat 200mg Tablets should not be used, in case of lung cancer, being treated with platinum containing chemo drugs and taxol drugs Sorafenatable to cause heart problems, stop the medicine in case of dizziness, fainting, sweating or shortening of breath Sorafenat causes severe bleeding; care should be taken while getting Sorafenat 200mg Stop the Tablet Sorafenat 200mg in case of;
blood in urine or stools, blood while coughing, Vaginal bleeding Hemorrhage risk QT prolongation. High occurrence of skin toxicity and rashes. Impairs exogenous thyroid suppression. Hypersentivity to the drug and any product of expicients.
SIDE EFFECT
Lymphopenia Neutropenia Hemorrhage Hypertension Neuropathy Anorexia Headache Joint pain Congestive heart failure Acute renal failure Angiodema arrhythmia Interstitial lung disease Post marketing reports: Hypersensitivity reactions: angioedema, anaphylactic reaction Hepatobiliary disorders: hepatitis, hepatic failure and death Musculoskeletal: rhabdomyolysis, osteonecrosis of the jaw Pulmonary: interstitial lung disease
PREGNANCY
Category D: Sorafenat 200mg Tablets can harm to an fetus and cause injury and even death to the unborn baby if you treatment during the 2nd and 3rd trimesters of pregnancy, pregnant women do not use the Sorafenat 200mg medicine without the knowledge of your doctor.LACTATION
The medicine passes into breast milk is not known or could harm a new born baby. Do not use Sorafenat 200mg Tablets medication, if your breast feeding.STORAGE
Sorafenat 200mg should be store at 25°C (77°F); excursion are allowed between 15°C and 30oC (59°F and 86°F) Protect from moisture, heat and lightMISSED DOSE
If patient missed to take Sorafenat 200mg Tablets , they may get advice from medical practitioner (consult) for administration of the missed dose within the time Or the missed dose should be skipped and follow the next dosing schedule Do not have double the dose.CONTACT DETAILS
Email : millionhealthpharmaceuticals@gmail.comPhone Number : +91-9940472902
Website : https://millionpharma.com/sorafenat.php
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