Crizalk 200mg | Crizotinib capsules | MHP

                                     CRIZALK 200MG

DESCRIPTION

                               Crizalk 200mg is also known as tyrosine kinase inhibitor. It acts by inhibiting an enzyme called anaplastic lymphoma kinase (ALK).

Crizalk 200mg only acts entirely in cancer cells which have an overactive version of ALK. In 100 people (5%) About 5 with NSCLC have this. It is known as ALK positive disease
Crizalk 200mg capsule is a prescription drug which is used under supervision of medical oncologist.

Crizalk 200mg

INDICATION

                           Crizalk 200mg capsule is an antineoplastic drug which is; Indicated for treatment in patients who suffering from locally advanced or metastatic non-small cell lung cancer (NSCLC) which is anaplastic lymphoma kinase-positive as detected by an FDA-approved test
Indicated for metastatic NSCLC tumors that are ROS1-positive.

MECHANISM OF ACTION

                                                       Prohibitor of receptor tyrosine kinases containing ALK, Hepatocyte Growth Factor Receptor (HGFR, c-Met), and Recepteur d’Origine Nantais (RON)
The gene’s expression and signaling which contribute to raised cell multiplication and continuation of the tumors become stimulate following the expression of ALK oncogenic fusion proteins
Prohibits the signaling whichhelp the expression of these oncogenic fusion proteins, hencepreventing tumor cell proliferation

                                               
ADME

Maximum plasma concentration is 4 to 6 hours
Bioavailability was 43%.
Plasma protein bounding is 91%
Volume of distribution is 1772L
Crizalk metabolised by CYP3A4 and CYP3A5

Crizalk is excreted via feces 63% and 22% via urine and half -life is 42 hours

                                  

PRODUCTS DETAILS

                                           Brand :Crizalk 
                                           Ingredients : Crizotinib
                                           Strength : 200mg
                                           Manufactured : Pfizer Ltd
                                           Package : Pack of 60 Capsules.

DOSAGE MANAGEMENT

     Some patients are selected for the treatment with Crizalk 200mg based on ALK or ROS1 presences in tumor specimens
The recommended dosage of Crizalk is 250mg orally twice in a day
Crizalk 200mg capsule can be taken with or without food, until disease progression
The capsule Crizalk 200mg should be swallowed whole.
Crizalk 200mg capsule should not break, open, or chew the capsule

Dosage modification :

                                   Crizalk 200 mg taken orally twice daily for First dose reduction Crizalk 250 mg taken orally once daily for Second dose reduction
Permanently discontinue if unable to tolerate Crizalk 250 mg taken orally once daily.

PRECAUTIONS

                           When administrating Crizalk 200mg,Hepatotoxicity resulted, increase in ALT and total bilirubin resulted, regulate q2wk for 2 months, then monthly
Using Crizalk 200mg capsule will causes Interstitial lung disease/pneumonitis.
When Crizalk 200mg administratingQT interval prolongation resulted, do not use congenital long QT syndrome.
While on Crizalk 200mg capsule treatment, Symptomatic bradycardia resulted, containing syncope; do not use Crizalk 200mg combination with other drugs known to cause bradycardia; regulate heart rate and blood pressure regularly.
Serious visual loss is reported.
While administrating Crizalk 200mg to pregnant womenEmbryo-fetal toxicity will occur.

SIDE EFFECTS

• Edema

• Constipation
• Dizziness
• Increased liver enzymes
• Bradycardia
• Feeling sick
• Swelling of hands and feet’s
• Decreased appetite
• Fatigue
• Infection increased
• Breathlessness
• Eyesight changes
• Bowel changes
• Liver changes
• Skin rash

CONTACTS DETAILS

          EMAIL :           millionhealthpharmaceuticals@gmail.com

          PHONE NO :   +91-9940472902

          WEBSITE :      https://millionpharma.com/crizalk-200mg.php